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Salvianolic acid A
Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.
Catalog No. T6S0444Cas No. 96574-01-5
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Purity:100%
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Salvianolic acid A
Catalog No. T6S0444Alias Dan Phenolic Acid ACas No. 96574-01-5
Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $45 | In Stock | |
| 10 mg | $72 | In Stock | |
| 25 mg | $146 | In Stock | |
| 50 mg | $217 | In Stock | |
| 100 mg | $326 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier. |
| In vitro | METHODS: Five tumor cell lines, SKOV3, HeLa, NCI-H1975, DU145 and A549, were treated with Salvianolic acid A (1.56-100 µM) for 72 h. Cell viability was measured by CellTiter-Glo kit. RESULTS: The growth of SKOV3, HeLa, NCI-H1975, DU145 and A549 cells was inhibited with increasing concentrations of Salvianolic acid A, with IC50s of 30.84 µM, 15.85 µM, 10.19 µM, 9.512 µM and 6.461 µM, respectively. [1] METHODS: Rat cardiomyocytes H9C2 were treated with Salvianolic acid A (50 µM) and Doxorubicin (4 µM) for 12 h. Apoptosis was detected by TUNEL assay. RESULTS: The number of apoptotic cells increased significantly after Dox stimulation. H9C2 cells co-treated with Dox and Salvianolic acid A exhibited significantly lower apoptosis rates compared to cells exposed to Dox. Salvianolic acid A inhibited Dox-induced apoptosis in H9C2 cells. [2] |
| In vivo | METHODS: In order to investigate the effects on amnesia in mice, Salvianolic acid A (10-40 mg/kg) was administered orally once daily for five days to a C57BL/6 mouse model of amnesia induced by diazepam. RESULTS: Salvianolic acid A exerts an antiamnesic effect on diazepam-induced paracrine amnesia in mice by enhancing the antioxidant capacity of the hippocampus. [3] |
| Alias | Dan Phenolic Acid A |
| Molecular Weight | 494.45 |
| Formula | C26H22O10 |
| Cas No. | 96574-01-5 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (91.01 mM)  10% DMSO+90% Saline: 13 mg/mL (26.29 mM), Working solution is recommended to be prepared and used immediately. Ethanol: 10 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
10% DMSO+90% Saline/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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